The Indianapolis Colts have a very good chance of moving to 3-0 even if the Tennessee Titans were fully healthy, but Tennessee isn't. Not that any NFL game can be guaranteed, of course, but Indy is in prime position to be undefeated before the schedule gets a lot tougher.
Plus, while Tennessee is hosting the game in Nashville, the weather might actually be a disadvantage for them even while playing a team who players their own home games inside. Players need to stay fresh during games not to get worn out late in the game, but that likely will happen to the Titans.
According to the Weather Channel, there is a 50 percent chance of thunderstorms on Sunday afternoon (which could stop play), but the temperatures are what should concern the Titans. It's going to be hot (highs in the uppers 80s) and humid.
The heat in Nashville might allow the Indianapolis Colts to run over the Tennessee Titans
Meanwhile, Tennessee has injury concerns on both sides of the ball. Nashville's team should be able to do much offensively with much success because their offensive line is so banged up. Right tackle JC Latham will miss the game with a hip issue, and guard Kevin Zeitler is questionable with a biceps problem.
It is the defensive side that should most concern Tennessee, though. The Colts are likely to mix the run and pass, but ideally run the ball a lot with Jonathan Taylor. The Titans will be without defensive tackle T'Vondre Sweat (ankle), and cornerback L'Jarius Sneed is questionable.
Sweat being out alone is going to cause Tennessee to have less quality in its D-line rotations, and this could mean the Titans get tired faster in the extreme heat of Nashville. If this occurs, and it is likely, then Jonathan Taylor might have even more success in the second half of the game than the first.
Indy fans should expect a run-heavy attack against Tennessee anyway. The Titans are terrible against the run. Through two games, they have allowed 5.5 yards per carry (30th in the league) and 150 yards rushing per game (29th). Ultimately, due to injuries and the heat, Tennessee players might find themselves deeply tired and constantly being run over by the fourth quarter.