The Indianapolis Colts have done a lot of things correctly in 2025 through five games. They have won close games, but steamrolled opponents in three weeks, too. What Indy hasn't had to do is win a close, low-scoring game.
That might need to be the case in Week 6 when the Arizona Cardinals visit Lucas Oil Stadium. While the Cards have not had an explosive offense yet this season, and still might not depending on the health of quarterback Kyler Murray, their defense has been mostly excellent.
This is especially true when it comes to stopping the run. Arizona has allowed the lowest EPA per designed carry this season, and is seventh-best in yards allowed per rush at 3.9. Teams have also scored just three times running the ball against the Cardinals.
Indianapolis Colts might have to throw to win in Week 6 versus the Arizona Cardinals
Meanwhile, Indianapolis, with star running back Jonathan Taylor, needs to be able to rely on running the ball exceedingly effectively to have a productive offense. Quarterback Daniel Jones has been great, but he's been able to build on what Taylor and the running attack have done.
Indy is ninth in rushing yards per game at 128.2, but leads the NFL in rushing touchdowns with 11. If the team is forced to throw in high volume, there is no guarantee the Indy offense will work well. Fans might find that out in Week 6.
In other words, Colts fans might find out as much about their favorite team against the Arizona Cardinals as at any point this season. Is Lou Anarumo's defense good enough to limit another offense when Indianapolis's own offense is limited? Indy's pass defense has allowed the second-most receptions to wide receivers this season, and the Cards have an emerging star.
Marvin Harrison Jr., son of Indianapolis's icon Marvin Harrison, didn't have a great rookie season, but after a slow start in year two, he has been good in the past two games. He might be figuring out things no matter who his quarterback is. (Murray might miss the game with a foot injury.)
If Harrison Jr. explodes for a huge game while the Indianapolis Colts struggle to run, Arizona is capable of springing the upset. Falling to 4-2 would not be the end of the season, of course, but Indy taking all its winnable games is important.
Or, it could be that the Arizona Cardinals simply haven't faced a running back like Jonathan Taylor. Maybe they contain Taylor in the first half, but he runs for 80 yards and two touchdowns in the second half. If that happens, Indianapolis wins.