Colts vs. Titans prediction, odds, spread, injuries, trends for NFL Week 13

A full betting preview for the Indianapolis Colts' Week 13 matchup against the Tennessee Titans.

Indianapolis Colts wide receiver Michael Pittman Jr. (11) rushes the ball Sunday, Nov. 26, 2023,
Indianapolis Colts wide receiver Michael Pittman Jr. (11) rushes the ball Sunday, Nov. 26, 2023, / Robert Scheer/IndyStar / USA TODAY
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The Indianapolis Colts are currently the seventh seed in the AFC playoff standings, which is amazing to think about as they lost rookie QB Anthony Richardson to a season-ending injury and didn’t have Jonathan Taylor to start the season. 

But to head coach Shane Steichen’s credit, this Colts team plays hard, which has them on a three-game winning streak. The Tennessee Titans will try to snap the Colts’ latest win streak after they defeated the Carolina Panthers last week.

The Colts opened as two-point favorites over the Titans, but that number has moved to 1.5 points due to the uncertainty around Taylor, who suffered a thumb injury in last week’s win against the Bucs.

If Taylor cannot play on Sunday afternoon, it could make the Titans a live underdog. However, rookie QB Will Levis’ production has started to level off after his debut last month against the Falcons.

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Colts vs. Titans Odds, Spread and Total

Colts vs. Titans Betting Trends

  • The Colts are 4-1 ATS on the road this season
  • Indianapolis is 1-5 ATS in its last six games vs. Tennessee
  • The Titans are 4-1 ATS at home this season
  • The UNDER is 4-1 in Tennessee’s last five games vs. Indianapolis

Colts vs. Titans Injury Reports

Colts Injury Report

  • Jonathan Taylor - RB - Questionable
  • Drew Ogletree - TE - Questionable
  • Ryan Kelly - C - Questionable
  • JuJu Brents - CB - Questionable

Titans Injury Report

  • Terrell Edmunds - S - Questionable
  • Treylon Burks - WR - Questionable
  • Chris Hubbard - OT - IR

Colts vs. Titans How to Watch

  • Date: Sunday, Dec. 3
  • Game Time: 1 p.m. EST
  • Venue: Nissan Stadium
  • How to Watch (TV): CBS
  • Colts Record: 6-5
  • Titans Record: 4-7

Colts vs. Titans Key Players to Watch

Indianapolis Colts

Michael Pittman Jr.: The young wide receiver had a tremendous performance against the Tampa Bay Buccaneers last week. The Colts took advantage of the Bucs missing Jamel Dean as Pittman Jr. recorded 10 receptions (13 targets) for 107 yards. The former USC standout has played well over the last few weeks with 26 catches (33 targets) for 255 yards. If Taylor can’t go on Sunday, we should expect a healthy target share against the Titans.

Tennessee Titans

Derrick Henry: Henry finally saw the end zone for the first time since Week 9 against the Steelers. The star running back had 76 yards and two touchdowns on 18 carries. It wasn’t a vintage performance from Henry, but it was enough to help the Titans win. 

The Colts have struggled to stop the run this season, allowing 129.3 yards per game and 15 TDs. If there was a game for Henry to remind everybody who is, this is the week to do it.

Colts vs. Titans Prediction and Pick

The Buccaneers tried to hold the Colts under 20 points in Week 12, and it didn’t work, as they scored 27. The Colts have one of the best scoring offenses in the league despite not having their dynamic dual-threat QB (Richardson). 

Minshew II does a solid job of not losing the game for the Colts, and they have a solid running game with Taylor and Zack Moss. Even with Taylor banged up, the Colts have a ton of faith in Moss to get the job done. If Indianapolis can control the LOS on Sunday, it will go a long way in determining the result.

As for the Titans, Levis didn’t play spectacularly, but he did his job. For Tennessee to upset the Colts on Sunday, they need their young quarterback to work the short, intermediate, and deep passing games. Henry hasn’t done much against the AFC South this season (3.5 YPC and zero touchdowns), but he looked good running the ball last week. 

With these two teams being close in talent, I like the UNDER in this spot, as we could see a 20-16 or 20-17 game.

Game odds refresh periodically and are subject to change.