Colts vs. Chargers prediction and odds for Week 16

Dec 17, 2022; Minneapolis, Minnesota, USA; Indianapolis Colts safety Julian Blackmon (32) reacts to a fourth down stop during the first quarter against the Minnesota Vikings at U.S. Bank Stadium. Mandatory Credit: Matt Krohn-USA TODAY Sports
Dec 17, 2022; Minneapolis, Minnesota, USA; Indianapolis Colts safety Julian Blackmon (32) reacts to a fourth down stop during the first quarter against the Minnesota Vikings at U.S. Bank Stadium. Mandatory Credit: Matt Krohn-USA TODAY Sports /
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The Indianapolis Colts are back in primetime taking on the Los Angeles Chargers. Here are the odds and a prediction for the Week 16 matchup.

It’s been a rough season for the Indianapolis Colts, especially in recent games. Not only is Indianapolis 4-9-1, but Indy has experienced some embarrassingly bad losses. First, it was losing to the Dallas Cowboys 54-19 on Sunday Night Football, then it was blowing a 33-point lead, the largest blown lead in league history, to the Minnesota Vikings. Now, the Colts will try to rebound on Monday Night Football against the Los Angeles Chargers.

The Chargers are 8-6 and fighting for a playoff spot. They are an immensely talented team and are led by Justin Herbert at quarterback. Los Angeles dealt with a lot of injuries earlier in the season but it is getting healthy at the perfect time and should provide Indianapolis with another challenging nationally televised game. What are the odds Indy can pull out a win?

Colts vs. Chargers odds Week 16

According to FanDuel, Indianapolis is +166 underdogs (bet $100 to win $166). Los Angeles, on the other hand, is the favorite with -198 odds (bet $198 to win $100). These odds shouldn’t come as a surprise since Indy has been struggling to win. However, it is expected to be a close game.

FanDuel has the spread set at 3.5 points. The odds of the Chargers winning by four or more points are -118 (bet $118 to win $100) and the odds of Indianapolis losing by three points or less are -104 (bet $104 to win $100).

The over/under for this game is set at 46.5 points with the odds for the over and under at -110. That means a $110 bet on the over will win $100 if the combined points equal 47 or more and a $110 bet on the under will win $100 if the combined points equal 46 or less.

Colts vs. Chargers prediction Week 16

Despite Indianapolis’ 4-9-1 record, the team often finds ways to be in competitive games. Oftentimes, it’s Indy’s defense that keeps the team hanging around before they ultimately lose. Well, the Chargers seem to only play in close games. Win or lose, Los Angeles is prone to one-possession games. That gives the Colts a chance to pull off an upset.

While this game will probably be close, expect Indianapolis to lose another heartbreaker. In these tight games this season, Indy typically loses and the Chargers find ways to win. That’s why the teams have opposite records. Indy is likely heading to a double-digit loss season on Monday.

Colts 14, Chargers 20

Game odds refresh periodically and are subject to change.