Colts Game Sunday: Colts vs Seahawks odds and prediction for NFL Week 1 game

After an offseason that seemingly tried whatever it could to derail the momentum this organization has picked up, the Indianapolis Colts are finally ready to suit up and make a run at the AFC South crown that eluded them last season.

Fresh off of the COVID-19 list, Carson Wentz’s first opponent as he tries to rehabilitate his stock in the NFL will be Russell Wilson, Jamal Adams, and the Seattle Seahawks. Like Indy, they are also trying to knock off the division favorite in the NFC West.

At the very least, Week 1 promises plenty of fireworks. With Indianapolis ready to air it out with Wentz, Seattle promises to be just as deadly thanks to new offensive coordinator Shane Waldron and a group of receivers led by DK Metcalf, Tyler Lockett, and speedy rookie D’Wayne Eskridge.

The Colts are going to have to scratch and claw for a victory in this game. Will they start the season off well in a winnable division? Or will Seattle’s offensive talent hand them a Week 1 loss?

Colts vs Seahawks Odds Week 1

The folks at WynnBet seem to think that Pete Carroll and Seattle will be the winner in this one. Seattle is a -3 favorite against the spread, which you can bet at +100. Indianapolis is -120 (bet $120 to win $100) to cover at +3.

The over-under is 50. You can take the over or under at -110 (bet $110 to win $100).

Colts Injury Report vs Seahawks Week 1

Check back for an official update and full injury report closer to game time!

Colts vs Seahawks Prediction Week 1

While Indianapolis and Seattle both have enough star power on both sides to theoretically pull out a victory here, the biggest obstacle in the way of a W for the Colts is their secondary. With tons of moving parts and not a much depth, this can be exploited by a clever offense.

Expect Wentz to have a solid game, showing off most of the skills that made him a dominant player in Philadelphia. However, Wilson might out-play him due to the fact he can lean on a superior core of pass-catchers, and that edge could help the Seahawks come out as the winner in this game.

Seahawks 27, Colts 20

Colts Next Game & Schedule

Indianapolis won’t get to take it easy after this one, as they have a matchup with a Super Bowl contender in the Los Angeles Rams in Week 2. They’ll follow that up with a game against the division-rival Tennessee Titans in Week 3 and the feisty Miami Dolphins in Week 4. Brutal.

Make Your Pick Now on WynnBet.

What Channel is the Colts Game On Week 1?

This Week 1 matchup between Seattle and Indianapolis will be shown at 1:00 p.m. ET/12:00 p.m. CT on FOX.

Colts vs Seahawks Live Stream

If you’re interested in a live stream, try a free trial of fuboTV!

Colts: Kwity Paye should be a DROY favorite after strong preseason

Colts defensive end Kwity Paye recorded a sack against the Vikings and Lions, and he left the preseason as the highest-graded rookie defender.