Colts vs. Titans Week 5 Opening Odds Give Indy Huge Opportunity in AFC South

The Colts sit atop the AFC South after falling just short of a huge comeback win against the Rams on Sunday. Indy now turns its attention to the Tennessee Titans in what'll be a huge test for rookie QB Anthony Richardson.

Tennessee trounced an overmatched Bengals squad yesterday, though this will be the Titans' first time seeing Richardson. The fourth overall pick was impressive against Los Angeles and this game is an important test for his development.

Before we look at the odds, make sure you've claimed your GUARANTEED $200 bonus from FanDuel Sportsbook. New users who sign up, deposit at least $10 and then bet $5 or more on the Colts will win $200 in bonus bets guaranteed! Sign up for FanDuel now, then check out the opening odds below.

Titans vs. Colts Week 5 Opening Odds

Despite the Titans' dominant Week 4 win, the Colts are a slight home favorite over Tennessee this week.

Indianapolis's offense has been impressive to this point and Anthony Richardson looks like a legitimate QB you can build around. His talent jumps off the screen and his rushing ability gives the offense a new dimension to utilize.

Tennessee's defense is a critical test, though. Mike Vrabel is one of the league's best coaches and the Titans are 13-6-1 against the spread in their last 20 games as underdogs.

If the Colts pull off the win, they'll officially be ahead of schedule and in the drivers' seat for the AFC South title. Containing Derrick Henry is no easy feat, but Indianapolis has an excellent opportunity to firmly enter the playoff race with a victory.

Indy has five straight losses to the Titans, so this is easily the most important game of the season thus far. Let's see if Richardson can deliver the Colts some early-season glory.

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Game odds refresh periodically and are subject to change.