Colts vs. Panthers prediction, odds, spread, injuries, trends for NFL Week 9

A full betting preview for NFL Week 9 action between the Colts and Panthers

Indianapolis Colts quarterback Gardner Minshew (10) hands the ball off to Indianapolis Colts running
Indianapolis Colts quarterback Gardner Minshew (10) hands the ball off to Indianapolis Colts running / Clark Wade/IndyStar / USA TODAY NETWORK

The Indianapolis Colts have suffered tough losses in two straight games, but they shouldn't give up on their season quite yet. Their Week 9 showdown in Carolina against the Panthers is virtually a must-win if they want to get back into the conversation for a potential wild card spot.

The Panthers will enter their game fresh off their first win of the season, beating another AFC South team in the Houston Texans.

In this article, I'm going to break down everything you need to know to bet on this game. Meanwhile, if you want my pick for the rest of the Week 9 action, be sure to check out this week's edition of the "Road to 272 Bets".

I bet on this game at Caesars Sportsbook and I encourage you to do the same. For a limited time, if you sign up for an account with the link below, you'll receive your first bet on Caesars, up to $1,000!

Colts vs. Panthers odds, spread, and total

Colts vs. Panthers betting trends

  • The OVER is 8-2 in the Colts' last 10 games
  • Colts are 3-12 straight up in their last 15 games
  • The OVER is 6-1 in the Colts' last seven road games
  • The Panthers are 1-4 ATS in their last five games vs. Colts
  • The UNDER is 6-2 in the Panthers' last eight home games
  • Panthers are 11-1 straight up in their last 12 games vs. AFC South opponents
  • Panthers are 1-5-1 ATS in their last seven games when set as underdogs.

Colts vs. Panthers injury reports

Indianapolis Colts injury report

  • Zaire Franklin - LB - Questionable
  • JuJu Brents - CB - Questionable
  • Kylen Granson - TE - Questionable
  • Eric Johnson - DT - Questionable
  • Braden Smith - OT - Questionable

Carolina Panthers injury report

  • Justin Houston - LB - Questionable
  • Vonn Bell - S - Questionable
  • Laviska Shenault Jr. - WR - Questionable

Colts vs. Panthers how to watch

  • Date: Sunday, November 5
  • Game Time: 4:05 pm et
  • Venue: Bank of America Stadium
  • How to Watch (TV): CBS
  • Indianapolis Colts Record: 3-5
  • Carolina Panthers Record: 1-6

Colts vs. Panthers key players to watch

Indianapolis Colts

Jonathan Taylor: This is a great matchup for the Colts' running backs. They get to face a Panthers team that arguably has the worst run defense in the NFL. They rank 32nd in opponent EPA/Rush and 31st in opponent success rate. That's good news for Jonathan Taylor and Zack Moss.

Carolina Panthers

Adam Thielen: It's clear that the Panthers' passing offense goes through Adam Thielen. He has 38 more receptions than the next closest receiver, which is an unbelievable gap. The Panthers better hope he stays healthy if they want any hope of winning any more games.

Colts vs. Panthers prediction and pick

The Panthers got their first win of the season, but I'm not convinced they can do the same thing against the Colts. They still rank 30th in terms of net yards per play at -1.2 while the Colts are 12th at +0.1.

Look for the Colts' running backs to have a big game this week. The Panthers are 32nd in opponent EPA per rush and 31st in opponent rush success rate. Meanwhile, the Colts average 4.5 yards per rush which ranks sixth in the NFL.

This is a much worse stylistic matchup for the Panthers than last week's game when they faced a Texans team that can't run the football. Now, the take on a Colts team that is just as effective through the air, but also has a solid running game to compliment it.

I'll back the Colts to win and cover the short spread.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!