The Colts must turn to Gardner Minshew this week against the Jaguars after Anthony Richardson suffered a shoulder injury that'll keep him out multiple weeks.
Indianapolis faces an uphill battle, though the Colts have covered the spread in three of their last four games in impressive fashion. Jacksonville, to its credit, picked up a great win over Buffalo in London, but now must travel back to the United States to get set for this matchup.
Nonetheless, oddsmakers expect the Colts to struggle on the road in Week 6 and expect a Jaguars win. Let's take a look at the opening odds and how you can guarantee you're a winner with a special FanDuel sign-up promo.
Colts vs. Jaguars Week 6 Opening Odds
Minshew is as capable a backup as there is in the league, so the Colts are in relatively good hands without Richardson. The Jaguars are a difficult matchup, but they're coming off a hard-fought battle overseas and this may be the perfect time for Indy to catch them jet-lagged.
It's only been a couple of weeks since the Texans trounced Jacksonville, 37-17, after all, and the Colts did beat the Jags last season with an inferior team.
The Jaguars got the best of Indianapolis in Week 1 this year, but the Colts now have film to watch and can make improvements with Minshew under center.
Jacksonville is only 3-7 against the spread in its last 10 games as a favorite, giving Indy an opportunity to take advantage of an inflated spread.
Colts fans can GUARANTEE they're winners this week thanks to a special new sign-up promo from FanDuel Sportsbook. New users who deposit at least $10 and then bet $5 or more on any Colts bet will win a guaranteed $200 in bonus bets! Even if you lose, you'll get the $200 bonus just for trying.
There's no better way to enjoy this Week 6 matchup than with an automatic win. Sign up for FanDuel now!
Game odds refresh periodically and are subject to change.